NIHR | Manchester Biomedical Research Centre
Our Research: Respiratory


We work closely with NIHR Biomedical Research Centres and other parts of NIHR infrastructure:

NIHR Senior Investigators
Our Respiratory theme joins researchers with charities, industry and key infrastructure support to combat the burden of respiratory diseases.

These include:


In the UK, our theme is part of the MRC funded COPD-MAP and founding partner of the UK Early COPD cohort funded by the British Lung Foundation and industry. We are part of the recently established European project CADSET – Chronic Airway Diseases Stratification by Endotypes. We are world-leading in clinical trials in COPD and work with almost all pharmaceutical companies with an interest in COPD.


Our fungal disease research is undertaken in the UK and across the world, currently in Uganda, Nigeria and Indonesia. We partner with diagnostic and antifungal development companies to deliver a better understanding of fungal diseases, optimise diagnostics and therapies, and identify resistance. A major theme is chronic pulmonary aspergillosis after Tuberculosis (TB), on which we have worked with the World Health Organisation to develop a definition of disease for low resource settings. Fungal diagnostic provision is part of the solution to AMR, to reduce antibacterial empiricism.


Our theme is mainly focused on understanding mechanisms in refractory and unexplained chronic cough supporting a Wellcome Investigator Award exploring the role of ATP in Chronic Cough. We are leading trials to assess novel therapies for chronic cough using our cough monitoring system, in particular a new class of therapies known as P2X3 antagonists. We are also part of the European Respiratory Society (ERS) funded NeuroCough registry. Finally we are investigating the hazards of indoor and outdoor pollution and developing tools to test and treat Inducible laryngeal obstruction.